Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease, characterized by the production of unusual antibodies that can attack patient’s own tissues and organs. In fact, inflammation caused by SLE can affect many different body systems — including skin, joints, blood cells, brain, kidneys, lungs and heart. The manifestation of multiple organ damages can mutually develop in the same time or different episodes (known as flares). Signs and symptoms may appear suddenly or develop slowly. And they can be mild or severe and may be temporary or permanent. Since the exact causes of SLE remain unknown, therefore it is essential to know and be aware of warning signs indicating SLE, allowing for an early diagnosis and effective treatment in a timely manner.